Perioperative medicine & outcomes
Intraoperative hypotension in noncardiac surgery patients with chronic beta-blocker therapy: A matched cohort analysis
Authors' conclusion
In this matched cohort analysis, chronic beta-blocker therapy was not associated with increased exposure to intraoperative hypotension in patients undergoing intermediate- to high-risk noncardiac surgery.
Study context
- Population
- Patients ≥60 years undergoing intermediate- to high-risk noncardiac surgery with routine postoperative troponin measurements on the first 3 days1,468 matched sets
- Exposure
- Chronic beta-blocker therapy vs no beta-blocker
- Outcome
- Exposure to intraoperative hypotension, beta-blocker users vs non-users
Methodological detailsmatched cohort (1:1 with replacement)
- Matched cohort (1:1 with replacement)
Main finding
As reported in the abstract
- No increased exposure to intraoperative hypotension in beta-blocker users for all characteristics and thresholds
- all P > .05
Observational data: associations, not effects.
Secondary outcomes
30-day mortality
P = 0.055
| Outcome | P value |
|---|---|
| Heart rate before, during and after surgery | P < 0.001 |
- Heart rate before, during and after surgery: before 70 vs. 74, during 61 vs. 65, after 68 vs. 74 bpm; all P < .001
Heart rate before, during and after surgery
- Beta-blocker users had lower heart rate before, during and after surgery
30-day mortality
- Comparable rates
Beta-blocker subtype and patient subgroups (subgroup)
- Results consistent in subtype and subgroup analyses
Safety
Postoperative myocardial injury
P = 0.269
30-day MI
P = 0.944
30-day stroke
P = 0.474
Postoperative myocardial injury
- Comparable rates
30-day myocardial infarction (MI)
- Comparable rates
30-day stroke
- Comparable rates
Original publication
Intraoperative hypotension in noncardiac surgery patients with chronic beta-blocker therapy: A matched cohort analysis. J Clin Anesth. Published 20 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →