Perioperative medicine & outcomes
Proactive vs Reactive Treatment of Hypotension During Surgery: The PRETREAT Randomized Clinical Trial
Primary result · WHODAS 2.0 scoreResult — go to the resultMean difference −0.5 95% CrI −1.9 to 0.9- stopped early for futility
- Stopped early for futility after 3247 of 5000 planned patients
Authors' conclusion
Intraoperative blood pressure management with mean arterial pressure goals stratified by risk of hypotension did not improve functional disability at 6 months postoperatively compared with standard intraoperative blood pressure management.
Study context
- Population
- Adults undergoing elective noncardiac surgery at 2 tertiary hospitals in the Netherlandsof 5000 planned
- Participants
- 3,247 adults
- Comparison
- Proactive vs Standard
- Primary endpoint
- Functional disability (12-item WHODAS 2.0, range 0-100, higher = more disability; MCID 5 points)
- Follow-up
- 6 months
Methodological details2 tertiary hospitals
- 2 tertiary hospitals
Primary result
WHODAS 2.0 score
Mean difference
−0.5
95% CrI −1.9 to 0.9
By group
Proactive
17.7
mean · SD 20.1
Standard
18.2
mean · SD 20.5
Proactive vs Standard
mean difference −0.5 (95% CrI −1.9 to 0.9)
As reported in the abstract
Secondary outcomes
23 secondary outcomes (incl. quality of life, complications, mortality within 6 months)
- No significant differences in any of the 23 secondary outcomes
Original publication
Proactive vs Reactive Treatment of Hypotension During Surgery: The PRETREAT Randomized Clinical Trial. JAMA. Published 2 December 2025. doi:10.
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