Perioperative medicine & outcomes
The effect of proactive versus reactive treatment of hypotension on postoperative disability and outcome in surgical patients under anaesthesia (PRETREAT): clinical trial protocol and considerations
Study context
- Population
- Adult inpatients scheduled for elective non-cardiac surgery under general or central neuraxial anaesthesiaplanned
- Participants
- 5,000 inpatients
- Planned comparison
- Proactive vs reactive treatment of hypotension
- Primary endpoint
- Postoperative disability measured with the WHO Disability Assessment Score (World Health Organization Disability Assessment Score (WHODAS)) 2.0 questionnaire
- Follow-up
- 6 months
Methodological detailsmulticentre, adaptive, 1:1 allocation, computer-generated blocks of four, six, or eight, Intervention strategy evaluated and revised in adaptation cycles of 3 weeks during the first 6 months if necessary
- Multicentre
- Adaptive
- 1:1 allocation
- Computer-generated blocks of four, six, or eight
- Intervention strategy evaluated and revised in adaptation cycles of 3 weeks during the first 6 months if necessary
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
The effect of proactive versus reactive treatment of hypotension on postoperative disability and outcome in surgical patients under anaesthesia (PRETREAT): clinical trial protocol and considerations. BJA Open. Published 29 February 2024. doi:10.
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