Intraoperative methadone administration for total mastectomy: A single center retrospective study
Authors' conclusion
Our study suggests that the unique pharmacological properties of methadone, including a short onset of action when given intravenously, long-acting pharmacokinetics, and multimodal effects, are associated with better acute pain management after a total mastectomy.
Study context
- Population
- Adult women undergoing total mastectomy
- Participants
- 133 vs 2,192
- Exposure
- Intraoperative methadone vs conventional short-acting opioids
- Methadonen = 133
- Short-acting opioidsn = 2,192reference
- Outcome
- Postoperative pain intensity
- Follow-up
- Day 1 after surgery
Methodological detailssingle-centre, propensity-score matched (1:3 nearest matching)
- Single-centre
- Propensity-score matched (1:3 nearest matching)
Main finding
As reported in the abstract
- Primary outcome result not reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Intraoperative and postoperative opioid consumption (oral morphine equivalents)
- Significantly lower with methadone
Average pain intensity in postanesthesia care unit (PACU)
- Lower with methadone
Intraoperative non-opioid analgesia use
- Reduced with methadone
Original publication
Intraoperative methadone administration for total mastectomy: A single center retrospective study. J Clin Anesth. Published 23 August 2024. doi:10.
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