Intraoperative Methadone in Next-day Discharge Outpatient Surgery: A Randomized, Double-blinded, Dose-finding Pilot Study
Authors' conclusion
The most effective and well-tolerated single intraoperative induction dose of methadone for next-day discharge surgery was 0.25 mg/kg ideal body weight (median, 14 mg). Single-dose intraoperative methadone was analgesic and opioid-sparing in next-day discharge outpatient surgery.
Study context
- Population
- Patients undergoing next-day discharge outpatient surgery
- Comparison
- Intraoperative single-dose IV methadone (0.1, 0.2, 0.25 or 0.3 mg/kg ideal body weight) vs as-needed short-duration opioid
- Primary endpoint
- In-hospital (intraoperative and postoperative) opioid use
Methodological detailsdouble-blind, dose-escalation, feasibility and pilot study
- Double-blind
- Dose-escalation
- Feasibility and pilot study
Primary result
As reported in the abstract
Total in-hospital opioid use (IV MME)
Secondary outcomes
Intraoperative methadone dose
Home pain and opioid use (30-day diaries)
- Numerically lower in patients receiving methadone
Safety
Opioid-related side effects
- Not numerically different
Original publication
Intraoperative Methadone in Next-day Discharge Outpatient Surgery: A Randomized, Double-blinded, Dose-finding Pilot Study. Anesthesiology. Published 23 June 2023. doi:10.
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