Intraoperative pharmacologic opioid minimisation strategies and patient-centred outcomes after surgery: a scoping review
Authors' conclusion
We identified three potentially promising pharmacologic intraoperative opioid minimisation strategies that should be further assessed through systematic reviews and multicentre trials.
Study context
- Population
- Adult surgical patients in trials of intraoperative opioid minimisation strategies reporting ≥1 patient-centred outcome
- Participants
- 67,060 patients · 457 trials
- Comparison
- Intraoperative pharmacologic opioid minimisation strategies
- Outcome
- Patient-centred effectiveness of opioid minimisation strategies
Methodological detailsMEDLINE, Embase, CENTRAL, Web of Science, CINAHL searched from inception to February 2023, 24,842 citations screened; 2803 trials assessed intraoperative opioid minimisation
- MEDLINE, Embase, CENTRAL, Web of Science, CINAHL searched from inception to February 2023
- 24,842 citations screened; 2803 trials assessed intraoperative opioid minimisation
Main finding
As reported in the abstract
Trials with a patient-centred primary outcome
107
Patient wellbeing the most frequently used domain (trials)
55
Further findings
Trials not reporting a protocol or registration number
- Almost half of trials
- 253
Original publication
Intraoperative pharmacologic opioid minimisation strategies and patient-centred outcomes after surgery: a scoping review. Br J Anaesth. Published 8 February 2024. doi:10.
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