ICU sedation, delirium & recovery
Target-controlled infusion for analgesia and sedation in the intensive care unit: a scoping review
Authors' conclusion
Available data suggest that TCI-based analgosedation in the ICU is feasible and safe in the short term. Most available data are descriptive or exploratory and robust comparative clinical benefit has not yet been demonstrated.
Study context
- Population
- Critically ill adults receiving analgesia and sedation in the intensive care unit (ICU)33 articles
- Participants
- 1,273 adults
- Comparison
- Target-controlled infusion (TCI)-based vs conventional analgosedation
- TCIn = 1,142 1
- Conventionaln = 106reference
- Outcome
- Applications of TCI in the ICU
Methodological detailsregistered protocol (Open Science Framework), randomised and non-randomised studies, Systematic search of major databases; 8 independent reviewers for screening, data extraction and risk of bias assessment
- Registered protocol (Open Science Framework)
- Randomised and non-randomised studies
- Systematic search of major databases; 8 independent reviewers for screening, data extraction and risk of bias assessment
Main finding
As reported in the abstract
- Studies directly comparing TCI-based with conventional analgosedation
- 4
Original publication
Target-controlled infusion for analgesia and sedation in the intensive care unit: a scoping review. Ann Intensive Care. Published 13 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →