ICU sedation, delirium & recovery
Target controlled infusion in the intensive care unit: a scoping review
Authors' conclusion
while current findings are promising, the evidence base supporting TCI-especially in the context of newer, generalized pharmacokinetic models and antibiotics-remains insufficient
Study context
- Population
- Adult intensive care unit (ICU) patients receiving target-controlled infusion (TCI) for any drug281 studies identified
- Outcome
- Use of TCI in the ICU (sedation, analgesia, antibiotics)
Methodological detailssystematic literature search (Medline, Cochrane Library, to August 2024)
- Systematic literature search (Medline, Cochrane Library, to August 2024)
Main finding
As reported in the abstract
Studies focused on sedatives, particularly propofol and remifentanil (Marsh and Minto models)
14
Studies of antibiotic TCI (mainly vancomycin, cefepime): potential but lacking robust clinical validation
3
Original publication
Target controlled infusion in the intensive care unit: a scoping review. J Clin Monit Comput. Published 9 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →