ICU sedation, delirium & recovery
The relation between inflammatory biomarkers and drug pharmacokinetics in the critically ill patients: a scoping review
Authors' conclusion
Inflammatory biomarkers can offer valuable information regarding altered PK in critically ill patients.
Study context
- Population
- Critically ill patients31 studies
- Outcome
- Relationship between inflammatory biomarkers and pharmacokinetics (PK) parameters (absorption, distribution, metabolism and excretion)
Methodological detailsPRISMA guidelines, Medline, Embase, Web of Science and Cochrane searched (January 1946-November 2023); 4479 records screened
- PRISMA guidelines
- Medline, Embase, Web of Science and Cochrane searched (January 1946-November 2023); 4479 records screened
Main finding
As reported in the abstract
- Studies by absorption, distribution, metabolism and excretion (ADME) component: 2 absorption, 7 distribution, 17 metabolism, 6 excretion
- Absorption: higher inflammatory biomarkers may increase or decrease drug absorption depending on hepatic first-pass elimination
- Distribution: inflammation negatively correlated with drug protein binding capacity, positively with cerebrospinal fluid penetration, negatively with peritoneal penetration
- Metabolism: metabolizing capacity of most drugs inversely correlated with inflammatory biomarkers
- Excretion: inflammation can lead to reduced drug clearance, except in neonates
- Results available for a limited number of drugs; most studies examine only one ADME component
Original publication
The relation between inflammatory biomarkers and drug pharmacokinetics in the critically ill patients: a scoping review. Crit Care. Published 19 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →