ICU sedation, delirium & recovery
The urea-to-creatinine ratio as an emerging biomarker in critical care: a scoping review and meta-analysis
Authors' conclusion
UCR elevations during critical illness potentially indicate muscle protein catabolism and the progression to persistent critical illness, and high levels at ICU admission could be associated with mortality.
Study context
- Population
- Critically ill adults with at least a single reported urea-to-creatinine ratio (UCR) value47 studies
- Comparison
- UCR ≥ 20 vs < 20 at intensive care unit (ICU) admission
- Outcome
- In-hospital mortality
Methodological detailsPRISMA Extension for Scoping Reviews
- PRISMA Extension for Scoping Reviews
Pooled result
As reported in the abstract
Each group vs < 20Estimate (95% CI)
≥ 20
RR 1.60(1.27–2.00)
≥ 20
aHR 1.29(0.89–1.86)
Further pooled results
- UCR inversely correlated to muscle cross-sectional area over time and associated with ICU LOS
Original publication
The urea-to-creatinine ratio as an emerging biomarker in critical care: a scoping review and meta-analysis. Crit Care. Published 2 May 2025. doi:10.
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