ICU sedation, delirium & recovery
Impact of pre-admission functional status on intensive care patient outcomes: a systematic review and meta-analysis
Authors' conclusion
Pre-admission frailty and functional dependency were associated with higher mortality after ICU admission.
Study context
- Population
- Acutely admitted adult ICU patients with reported pre-admission functional status55 observational studies
- Comparison
- Non-frail vs frail and independent vs dependent pre-admission functional status
- Outcome
- All-cause mortality
- Follow-up
- Variable (ICU to 1 yr)
Methodological detailsGRADE certainty assessment, duplicate screening and data extraction
- GRADE certainty assessment
- Duplicate screening and data extraction
Pooled result
As reported in the abstract
Relative risk (95% CI)P value
Non-frail vs Frail
0.62(0.58–0.67)
P < 0.01Independent vs Dependent
0.47(0.40–0.54)
P < 0.01Further pooled results
Overall mortality · variable follow-up (ICU to 1 yr)
- Participants deceased
- 26.7%
Prevalence of frailty and functional dependency
- Frailty prevalence range
- 3.6% to 76.8%
- Functional dependency range
- 10.6% to 68.7%
Exploratory outcomes (subgroup analysis)
- No statistically significant association
Original publication
Impact of pre-admission functional status on intensive care patient outcomes: a systematic review and meta-analysis. Br J Anaesth. Published 28 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →