ICU sedation, delirium & recovery
Mortality Predictions Including Pre‐Admission Functional Status in ICU Patients With Delirium—A Substudy of the AID ‐ ICU Trial
Authors' conclusion
The models showed fair discrimination and good calibration, with frailty, age, SMS-ICU, advanced cancer, and surgical admission as key predictors.
Study context
- Population
- Adult delirious ICU patients in the against Delirium in the Intensive Care Unit (AID-ICU) trial with pre-admission Clinical Frailty Scale, Comorbidity-Polypharmacy Score and Barthel-20 data
- Participants
- 630 vs 610
- Comparison
- 90-day mortality model vs 1-year mortality model
- 90-day mortality modeln = 630
- 1-year mortality modeln = 610
- Primary endpoint
- Prediction of 90-day and 1-year mortality (discrimination, calibration)
Methodological detailssubstudy of the AID-ICU randomised trial, internal validation by bootstrapping adjusting for optimism, elastic net regression, three highest-enrolling hospitals
- Substudy of the AID-ICU randomised trial
- Internal validation by bootstrapping adjusting for optimism
- Elastic net regression
- Three highest-enrolling hospitals
Primary result
As reported in the abstract
Optimism-adjusted AUC
| Group | AUC |
|---|---|
| 90-day mortality model | 0.74 (95% CI 0.70-0.78) |
| 1-year mortality model | 0.74 (95% CI 0.70-0.77) |
AUC
90-day mortality model0.74 (95% CI 0.70-0.78)
1-year mortality model0.74 (95% CI 0.70-0.77)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Mortality Predictions Including Pre‐Admission Functional Status in ICU Patients With Delirium—A Substudy of the AID ‐ ICU Trial. Acta Anaesthesiol Scand. Published 21 March 2026. doi:10.
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