ICU sedation, delirium & recovery
The value of right ventricular to pulmonary arterial coupling in the critically ill: a National Echocardiography Database of Australia (NEDA) substudy
Main finding · Death in ICU per higher TAPSE/TRV ratioResult — go to the resultHazard ratio 0.927 CI 0.872–0.985Authors' conclusion
The TAPSE/TRV ratio has prognostic relevance in critically ill patients. The prognostic power may be stronger in respiratory and septic subgroups.
Study context
- Population
- Intensive care unit (ICU) patients with echocardiography, January 2012 to May 2017
- Participants
- 1,077 patients
- Exposure
- Tricuspid annular plane systolic excursion (TAPSE)/tricuspid regurgitant velocity (TRV) ratio tertiles: middle and high vs low
- Outcome
- Death in ICU per higher TAPSE/TRV ratio
Methodological detailsregistry substudy (NEDA)
- Registry substudy (NEDA)
Main finding
As reported in the abstract
Hazard ratio
0.927
CI 0.872–0.985
P < 0.05
Higher TAPSE/TRV ratio
HR 0.927 (CI 0.872–0.985); P < 0.05
Per higher TAPSE/TRV ratio, as printed
- Higher overall survival in middle and high vs low tertiles (Kaplan-Meier, log rank)
- P < 0.0001
Observational data: associations, not effects.
Further findings
Diagnostic subgroups (subgroup)
- Prognostic relevance of TAPSE/TRV strongest in respiratory and sepsis subgroups
Ventricular dysfunction by tertile
- Higher proportions of ventricular dysfunction in low TAPSE/TRV tertiles
- TAPSE/TRV impacted by left ventricular (LV) systolic function, less than by right ventricular (RV) or biventricular dysfunction
Original publication
The value of right ventricular to pulmonary arterial coupling in the critically ill: a National Echocardiography Database of Australia (NEDA) substudy. Ann Intensive Care. Published 16 January 2024. doi:10.
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