ICU sedation, delirium & recovery
Right Ventricular Strain and Outflow Tract Velocity Time Integral Are Associated with Mortality in Critically Ill Patients with Pulmonary Embolism
Authors' conclusion
Among patients with PE in the ICU, right ventricular strain and RVOT VTI were associated with mortality in the ICU and at 6-month follow-up. Furthermore, right ventricular strain was independently associated with future heart failure.
Study context
- Population
- Patients with pulmonary embolism (PE) requiring ICU admission, June 1999 to December 2023386 treated with thrombolysis
- Participants
- 463 patients
- Outcome
- ICU mortality (multivariable associations)
Methodological detailsprospective inclusion, multivariable analysis
- Prospective inclusion
- Multivariable analysis
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
Pulmonary embolism severity index
1.241(1.037–1.587)
P < 0.001RVGLS
0.421(0.202–0.774)
P < 0.001Left atrial reservoir
0.357(0.141–0.756)
P < 0.001Right atrial pump (εa)
0.632(0.282–0.887)
RVOT VTI
0.678(0.321–0.881)
P < 0.001Left ventricular outflow tract VTI
0.782(0.413–0.912)
P < 0.001- ICU mortality
- 18.4%
Observational data: associations, not effects.
Further findings
6-month mortality (multivariable associations)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Pulmonary embolism severity index | 1.029 (1.012–1.377) | P < 0.001 | |
| RVGLS | 0.657 (0.438–0.871) | P < 0.001 | |
| RVOT VTI | 0.324 (0.102–0.541) | P < 0.001 | |
| Right atrial pump (εa) | 0.352 (0.193–0.721) | P < 0.001 | |
| Left ventricular outflow tract VTI | 0.814 (0.281–0.948) | P < 0.001 | |
| 0.10.31310Odds ratio (log scale) |
Development of HF at 6 months (multivariable associations)
| OR (95% CI) | P value | ||
|---|---|---|---|
| RVGLS | 0.538 (0.182–0.785) | P = 0.001 | |
| Left atrial strain (εa) | 0.313 (0.21–0.721) | P < 0.001 | |
| Pulmonary flow acceleration time in RVOT | 0.693 (0.328–0.839) | P < 0.001 | |
| Estimated pulmonary artery wedge pressure | 1.437 (1.131–2.274) | P < 0.001 | |
| Intracavitary thrombus | 1.223 (1.117–1.973) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
- 6-month mortality (multivariable associations) — 6-month mortality
- 20.7%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Right Ventricular Strain and Outflow Tract Velocity Time Integral Are Associated with Mortality in Critically Ill Patients with Pulmonary Embolism. Am J Respir Crit Care Med. Published 1 August 2025. doi:10.
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