Perioperative medicine & outcomes
Intraoperative pleth variability index-based fluid management therapy and gastrointestinal surgical outcomes in elderly patients: a randomised controlled trial
Primary resultResult — go to the resultOdds ratio 0.935 95% CI 0.541–1.615Authors' conclusion
Among elderly patients undergoing GI surgery, intraoperative GDFT based on the simple and non-invasive PVI did not reduce the occurrence of composite postoperative complications but was associated with a lower cardiopulmonary complication rate than usual fluid management.
Study context
- Population
- Older adults undergoing gastrointestinal (GI) surgery, two university teaching hospitals, November 2017 to December 2020
- Participants
- 220 adults
- Comparison
- Pleth variability index (PVI)-directed goal-directed fluid therapy (GDFT) vs conventional fluid therapy
- GDFTn = 110
- Conventional fluid therapy (CFT)n = 110reference
- Primary endpoint
- Composite of complications
- Follow-up
- Within 30 postoperative days
Methodological detailstwo-centre
- Two-centre
Primary result
As reported in the abstract
Odds ratio
0.935
95% CI 0.541–1.615
P = 0.809
By group
CFT vs GDFT
OR 0.935 (95% CI 0.541–1.615); P = 0.809
Secondary outcomes
| Outcome | GDFT | CFT | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Cardiopulmonary complications | 8.4% | 19.2% | 2.593 (1.120–5.999) | P = 0.022 | |
| 0.20.5125Odds ratio (log scale) |
Total fluid volume administered
P = 0.008
Time to first flatus, PONV, postoperative LOS
- No other differences between the two groups
Original publication
Intraoperative pleth variability index-based fluid management therapy and gastrointestinal surgical outcomes in elderly patients: a randomised controlled trial. Perioper Med (Lond). Published 12 May 2023. doi:10.
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