Cardiothoracic & vascular anesthesia
The effect of intraoperative goal-directed fluid therapy combined with enhanced recovery after surgery program on postoperative complications in elderly patients undergoing thoracoscopic pulmonary resection: a prospective randomized controlled study
Authors' conclusion
Under ERAS program, there was no significant difference of AKI incidence between GDFT and RFT in elderly patients undergoing thoracoscopic pulmonary resection. But postoperative increase degree of serum creatinine was lower in GDFT group.
Study context
- Population
- Patients >60 years undergoing thoracoscopic pulmonary resection for non-small cell lung cancer
- Participants
- 276 patients
- Comparison
- Goal-directed fluid therapy (GDFT) vs restrictive fluid therapy (RFT)
- GDFTn = 138
- RFTn = 138reference
- Primary endpoint
- Postoperative acute kidney injury (AKI)
Methodological detailsprospective
- Prospective
Primary result
As reported in the abstract
P = 0.317
Further findings
Postoperative increase degree of serum creatinine · lower in GDFT
P = 0.048
Events
| Outcome | GDFT | RFT |
|---|---|---|
| Composite postoperative complications | 66 | 70 |
Composite postoperative complications
- No significant difference between groups
Intraoperative fluids, urine output and norepinephrine
- Total infusion volume, colloid volume and urine output higher, norepinephrine dosage lower in GDFT vs RFT
Original publication
The effect of intraoperative goal-directed fluid therapy combined with enhanced recovery after surgery program on postoperative complications in elderly patients undergoing thoracoscopic pulmonary resection: a prospective randomized controlled study. Perioper Med (Lond). Published 10 July 2023. doi:10.
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