Cardiothoracic & vascular anesthesia
Effect of low-dose norepinephrine combined with goal-directed fluid therapy on postoperative pulmonary complications in lung surgery: A prospective randomized controlled trial
Authors' conclusion
Continuous low-dose norepinephrine infusion combined with GDFT reduced PPCs incidence in elective lung surgery patients compared with standard fluid management, but showed no difference compared to GDFT alone.
Study context
- Population
- Patients undergoing elective thoracoscopic lung resection surgery, single hospital, Anhui, China
- Participants
- 184 patients
- Comparison
- Low-dose norepinephrine + goal-directed fluid therapy (GDFT) vs GDFT alone vs standard fluid treatment
- Primary endpoint
- Incidence of PPCs (respiratory infection, atelectasis, pneumothorax, pleural empyema, respiratory failure, PE, bronchopleural fistula)
- Follow-up
- Postoperative hospital stay
Methodological detailsprospective, three-arm
- Prospective
- Three-arm
Primary result
As reported in the abstract
Odds ratio (95 % CI)P value
Group N vs Group C
2.98(1.17–8.31)
P = 0.023Group N vs Group G
1.31(0.46–3.91)
P = 0.616Secondary outcomes
Components of postoperative pulmonary complications (PPCs)
- No significant differences among the three groups
Intraoperative MAP and stroke volume index
- Higher in Group N vs Group C
Original publication
Effect of low-dose norepinephrine combined with goal-directed fluid therapy on postoperative pulmonary complications in lung surgery: A prospective randomized controlled trial. J Clin Anesth. Published 9 October 2024. doi:10.
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