Intraoperative Prophylaxis with Palonosetron for Postoperative Nausea and/or Vomiting in Adults Undergoing Cardiothoracic Surgery Under General Anesthesia: A Single-Center Retrospective Study
Authors' conclusion
This single-center retrospective study underscored palonosetron's efficacy, alone or combined with dexamethasone, in managing PONV among adult patients who undergo CTS.
Study context
- Population
- Adults undergoing cardiothoracic surgery under GA at Virginia Mason Medical Center, Seattle, September 2021–March 2023
- Participants
- 540 adults
- Exposure
- Palonosetron, dexamethasone, or both vs no antiemetic
- Outcome
- PONV incidence
- Follow-up
- Within 96 hours postoperatively
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
PONV incidence within 96 h
Odds ratio
0.24
Palonosetron
Odds ratio
0.26
Dexamethasone with palonosetron
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Palonosetron | No antiemetic |
|---|---|---|
| PONV 0–12 h (sensitivity analysis) · 0- to 12-hour | 9% | 28% |
PONV risk factors (Cox regression)
- Varying PONV HRs related to female sex, PONV history, and lower BMI
Original publication
Intraoperative Prophylaxis with Palonosetron for Postoperative Nausea and/or Vomiting in Adults Undergoing Cardiothoracic Surgery Under General Anesthesia: A Single-Center Retrospective Study. J Cardiothorac Vasc Anesth. Published 8 February 2024. doi:10.
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