Perioperative medicine & outcomes
Intraoperative Ventilation/Perfusion Mismatch and Postoperative Pulmonary Complications after Major Noncardiac Surgery: A Prospective Cohort Study
Main finding · Intraoperative V/Q distribution and PPCsResult — go to the resultAdjusted odds ratio 1.147 95% CI 1.021–1.289Authors' conclusion
In patients with intermediate or high risk of postoperative pulmonary complications undergoing major noncardiac surgery, intraoperative V/Q mismatch is associated with the development of postoperative pulmonary complications.
Study context
- Population
- Patients undergoing GA for major noncardiac surgery, intermediate or high risk of PPCs
- Participants
- 101 patients
- Exposure
- Patients with vs without PPCs
- PPCsn = 29
- Outcome
- Association of intraoperative V/Q mismatch (automatic lung parameter estimator) with PPCs
- Follow-up
- 7 days after surgery
Main finding
Intraoperative V/Q distribution and PPCs
Adjusted odds ratio
1.147
95% CI 1.021–1.289
P = 0.02
Patients with vs without PPCs (intraoperative V/Q distribution)
adjusted OR 1.147 (95% CI 1.021–1.289); P = 0.02
As reported in the abstract
Observational data: associations, not effects.
Further findings
High V/Q ratio during surgery
P = 0.007
| Outcome | PPCs | No PPCs | P value |
|---|---|---|---|
| Shunt at T1 | 22.4% (IQR 10.4–35.9%) | 19.3% (IQR 9.4–24.1%) | P = 0.18 |
Incidence of PPCs · 7 days
- Patients developing PPCs
- 29 (29%)
- Acute respiratory failure
- 23%
- Pleural effusion
- 11%
Sensitivity analysis (E-value)
- E-value
- 1.35
- CI, 1.11
Original publication
Intraoperative Ventilation/Perfusion Mismatch and Postoperative Pulmonary Complications after Major Noncardiac Surgery: A Prospective Cohort Study. Anesthesiology. Published 20 May 2024. doi:10.
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