Intrathecal Morphine for Enhanced Recovery After Laparoscopic Colorectal Surgery: A Randomized Clinical Trial
Primary result · QoR-15 scoreResult — go to the resultMean difference 12.21 95% CI 9.91–14.51Authors' conclusion
Per the results of this randomized clinical trial, in laparoscopic colorectal surgery, ITM combined with TAPB can significantly enhance early postoperative recovery and analgesia, albeit with an increased risk of pruritus.
Study context
- Population
- Adults scheduled for elective laparoscopic colorectal surgery, Sun Yat-sen University Cancer CenterITT analysis
- Participants
- 252 adults
- Comparison
- Intervention vs Control
- Primary endpoint
- QoR-15 score
- Follow-up
- 24 hours postoperatively
Methodological detailsprospective, double-blind, placebo-controlled, single-centre, Sun Yat-sen University Cancer Center, October 15, 2024, to February 15, 2025
- Prospective
- Double-blind
- Placebo-controlled
- Single-centre
- Sun Yat-sen University Cancer Center, October 15, 2024, to February 15, 2025
Primary result
As reported in the abstract
Mean difference
12.21
95% CI 9.91–14.51
P < 0.001
By group
Intrathecal morphine (ITM)
114.95
mean · SE 1.04
Control
102.22
mean · SE 0.76
ITM vs Control
mean difference 12.21 (95% CI 9.91–14.51); P < 0.001
Secondary outcomes
| Outcome | Control | Mean difference (95% CI) | P value | |
|---|---|---|---|---|
| Postoperative morphine consumptionITM vs Control | mean 10.4 (SD 11.1) MME | −6.59 (−8.88 to −4.31) | P < 0.001 | |
| −10−505Difference (linear scale) |
- Postoperative morphine consumption: ITM mean 4.4 (SD 6.4) MME
Safety
| Outcome | Intervention | Control | Adjusted risk difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Nausea | 23.8% | 37.3% | −15.06% (−26.60% to −3.52%) | P = 0.01 | |
| Pruritus | 19.0% | 3.2% | 15.08% (7.26%–22.90%) | P < 0.001 | |
| −40−2002040Difference (linear scale) |
Original publication
Intrathecal Morphine for Enhanced Recovery After Laparoscopic Colorectal Surgery: A Randomized Clinical Trial. JAMA Surg. Published 1 February 2026. doi:10.
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