Transversus abdominis plane block enhances analgesia and reduces opioid use after laparoscopic donor hepatectomy with intrathecal morphine: a randomized controlled trial
Primary resultResult — go to the resultMedian difference 3 95% CI 2–4Authors' conclusion
Bilateral TAPB combined with ITM significantly enhanced analgesia and reduced opioid requirements during the immediate postoperative period after PLDH in living liver donors. Additionally, TAPB improved the Quality of Recovery at 24 hours postoperatively.
Study context
- Population
- Living liver donors undergoing pure laparoscopic donor hepatectomy, Korea
- Participants
- 80 donors
- Comparison
- Transversus abdominis plane block (TAPB) vs Control
- Primary endpoint
- Worst pain score at rest in the postanesthesia care unit (PACU)
Methodological detailssingle-centre, Single centre in Korea, 9 May 2023 to 9 October 2024
- Single-centre
- Single centre in Korea, 9 May 2023 to 9 October 2024
Primary result
As reported in the abstract
Median difference
3
95% CI 2–4
P < 0.001
TAPB vs Control
median difference 3 (95% CI 2–4); P < 0.001
Further findings
| Outcome | P value |
|---|---|
| Cumulative opioid consumption · 1, 4 and 24 hours postoperativelyTAPB vs Control · 1 hour; significantly decreased in TAPB | P = 0.029 |
| Cumulative opioid consumption · 1, 4 and 24 hours postoperativelyTAPB vs Control · 4 hours | P = 0.023 |
| Cumulative opioid consumption · 1, 4 and 24 hours postoperativelyTAPB vs Control · 24 hours | P = 0.018 |
| Quality of Recovery-15K score · 24 hours postoperativelyHigher in TAPB | P = 0.030 |
Pain scores · up to 4 hour postoperatively
- Lower pain scores persisted in the TAPB group
Safety
Opioid-related complications
- Incidence comparable between groups
Original publication
Transversus abdominis plane block enhances analgesia and reduces opioid use after laparoscopic donor hepatectomy with intrathecal morphine: a randomized controlled trial. Reg Anesth Pain Med. Published 25 September 2025. doi:10.
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