Intrathecal Opioid Use in Kidney Transplantation: An Observational Cohort Study
Main findingResult — go to the resultRatio of geometric means 0.34 95% CI 0.26–0.43Authors' conclusion
Intrathecal opioid administration was associated with improved pain outcomes in patients undergoing kidney transplantation, including lower opioid requirements and pain scores through 72 hours.
Study context
- Population
- Kidney transplant operations at a single tertiary care medical center, August 1, 2017–July 31, 2022transplants in 1012 patients
- Participants
- 1,014 operations
- Exposure
- Intrathecal opioids before incision vs no intrathecal opioids
- Intrathecaln = 411
- No intrathecaln = 603reference
- Outcome
- Total postoperative opioid exposure (milligram morphine equivalents (MME))
- Follow-up
- First 72 hours postoperatively
Methodological detailssingle-centre, inverse probability of treatment weighting (IPTW)
- Single-centre
- Inverse probability of treatment weighting (IPTW)
Main finding
As reported in the abstract
72 hours
Ratio of geometric means
0.34
95% CI 0.26–0.43
P < 0.001
By group
Intrathecal vs No intrathecal
ratio of geometric means 0.34 (95% CI 0.26–0.43); P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Intrathecal | No intrathecal | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Maximum reported pain score · 24 hours | 4 (IQR 2–7) | 7 (IQR 5–8) | 0.28 (0.21–0.37) | P < 0.001 | |
| Maximum reported pain score · 72 hours | 6 (IQR 4–7) | 7 (IQR 5–8) | 0.41 (0.31–0.54) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
- Maximum reported pain score: for experiencing a higher pain score with intrathecal opioids
Safety
| Outcome | Intrathecal | No intrathecal | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| PONV | 55% | 38% | 2.16 (1.63–2.86) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
- PONV: 225 of 411 vs 232 of 603
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Intrathecal Opioid Use in Kidney Transplantation: An Observational Cohort Study. Anesth Analg. Published 6 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →