Preoperative Pregabalin and the Cp50 for Skin Incision During Target-Controlled Propofol Infusion: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial
Authors' conclusion
This study demonstrated that pretreatment with 300 mg pregabalin significantly reduced the Cp50 value of propofol by 44%, as calculated using the delta method.
Study context
- Population
- Female patients undergoing breast surgery with propofol target-controlled infusion (TCI) (Schnider model) as sole anesthetic, without opioids or other analgesics
- Participants
- 80 patients
- Comparison
- Pregabalin 300 mg vs placebo 2 h before induction
- Primary endpoint
- Propofol Cp50 for motor response to standardized skin incision (logistic regression, delta method)
Methodological detailsplacebo-controlled, double-blind
- Placebo-controlled
- Double-blind
Primary result
As reported in the abstract
Propofol Cp50
Secondary outcomes
Opioid consumption and pain in the recovery area
- Significantly decreased opioid consumption and pain levels with pregabalin vs placebo
Original publication
Preoperative Pregabalin and the Cp50 for Skin Incision During Target-Controlled Propofol Infusion: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial. Anesth Analg. Published 29 October 2025. doi:10.
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