Effect of Ketamine on the Bispectral Index, Spectral Edge Frequency, and Surgical Pleth Index During Propofol-Remifentanil Anesthesia: An Observational Prospective Trial
Authors' conclusion
Our results show that BIS and SEF 95 , but not SPI, follow a CeK-dependent trend after administering a ketamine bolus. Interestingly, their peak values were not reached at CeK=1 μg.mL -1 , but after several minutes after the drug infusion at CeKs in the 0.2 to 0.5 μg.mL -1 range.
Study context
- Population
- Adult female patients undergoing breast oncologic surgery under stable propofol-remifentanil target-controlled infusion (TCI) anaesthesia, given a ketamine bolus (target concentration of ketamine (CeK) 1 μg.mL −1, Domino model)
- Participants
- 14 patients
- Outcome
- Association between ketamine effect-site concentration (CeK) and BIS and spectral edge frequency (SEF 95 ) after a ketamine bolus
Methodological detailssingle-centre, Ketamine dose 0.57 mg.kg −1 (IQR 0.56-0.57 mg.kg −1 ); target CeK set to 0 once CeK reached 1 μg.mL −1
- Single-centre
- Ketamine dose 0.57 mg.kg −1 (IQR 0.56-0.57 mg.kg −1 ); target CeK set to 0 once CeK reached 1 μg.mL −1
Main finding
As reported in the abstract
BIS and SEF 95 vs CeK
Time to maximum BIS after CeK=1 μg.mL −1 (median [IQR])
16.0 minutes
10.2–22.7 minutes
CeK at maximum BIS
0.22 μg.mL −1
0.12–0.41 μg.mL −1
Time to peak SEF 95 after CeK=1 μg.mL −1
10.0 minutes
8.62–14.1 minutes
CeK at peak SEF 95
0.43 μg.mL −1
0.25–0.50 μg.mL −1
Observational data: associations, not effects.
Further findings
Surgical pleth index (SPI) vs CeK
- No significant association between CeK and SPI
Original publication
Effect of Ketamine on the Bispectral Index, Spectral Edge Frequency, and Surgical Pleth Index During Propofol-Remifentanil Anesthesia: An Observational Prospective Trial. Anesth Analg. Published 1 November 2024. doi:10.
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