Comparative Analysis of the Performance of Electroencephalogram Parameters for Monitoring the Depth of Sedation During Remimazolam Target-Controlled Infusion
Authors' conclusion
BIS, PSI, and RBR showed an acceptable correlation with the effect-site remimazolam concentration and depth of sedation in this study, suggesting that these EEG-derived parameters are potentially reliable hypnotic indicators during remimazolam sedation. BIS and PSI showed superior performance as hypnotic indicators to RBR and SEF in patients receiving target-controlled infusion of remimazolam.
Study context
- Population
- Patients undergoing lower extremity varicose vein or orthopedic surgery under spinal anesthesia, sedated with remimazolam TCI (Schüttler model)32 analyzed
- Participants
- 35 patients
- Exposure
- BIS vs patient state index (PSI) vs relative beta ratio (RBR) vs spectral edge frequency (SEF)
- Outcome
- Pk and Spearman's R of EEG parameters with effect-site remimazolam concentration and MOAA/S
Main finding
As reported in the abstract
Performance for effect-site remimazolam concentration
| Group | Pk | R |
|---|---|---|
| BIS | 0.76 [0.72-0.79], P < .001 | −0.70 [−0.78 to −0.63], P < .001 |
| PSI | 0.76 [0.73-0.79], P < .001 | −0.72 [−0.79 to −0.66], P < .001 |
| RBR | 0.71 [0.68-0.74], P < .001 | −0.61 [−0.69 to −0.54], P < .001 |
| SEF | 0.58 [0.53-0.63], P = .002 | −0.22 [−0.36 to −0.08], P = .002 |
Pk
BIS0.76 [0.72-0.79], P < .001
PSI0.76 [0.73-0.79], P < .001
RBR0.71 [0.68-0.74], P < .001
SEF0.58 [0.53-0.63], P = .002
R
BIS−0.70 [−0.78 to −0.63], P < .001
PSI−0.72 [−0.79 to −0.66], P < .001
RBR−0.61 [−0.69 to −0.54], P < .001
SEF−0.22 [−0.36 to −0.08], P = .002
Observational data: associations, not effects.
Further findings
| Outcome | BIS | PSI | RBR | SEF |
|---|---|---|---|---|
| Performance for MOAA/S | ||||
| Pk | 0.81 [0.79-0.83], P < .001 | 0.80 [0.78-0.83], P < .001 | 0.74 [0.72-0.77], P < .001 | 0.55 [0.50-0.59], P = .041 |
| R | 0.84 [0.81-0.88], P < .001 | 0.82 [0.78-0.87], P < .001 | 0.72 [0.65-0.78], P < .001 | 0.13 [−0.01 to 0.27], P = .067 |
Performance for MOAA/S
- BIS and PSI significantly higher Pk and R than RBR and SEF
Original publication
Comparative Analysis of the Performance of Electroencephalogram Parameters for Monitoring the Depth of Sedation During Remimazolam Target-Controlled Infusion. Anesth Analg. Published 5 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →