A Pilot Investigation Evaluating Relative Changes in Fronto-Occipital Alpha and Beta Spectral Power as Measurement of Anesthesia Hypnotic Depth
Authors' conclusion
FO-RPAB appears to qualify as a marker of unconsciousness, reflecting physiological fronto-occipital activity differences during GA. In contrast to frontal SEF-95, it is not disturbed by additional administration of ketamine for analgesia.
Study context
- Population
- Patients undergoing general anesthesia (GA) in ophthalmic surgery, Bern University Hospital
- Participants
- 32 patients
- Exposure
- Fronto-occipital RPAB (FO-RPAB) vs SEF-95
- Outcome
- Change in FO-RPAB during wakefulness, GA maintenance and emergence, and before/after ketamine bolus
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
FO-RPAB shift
- Significant FO-RPAB shift during both induction of and emergence from GA
- P < .001
- No significant change in FO-RPAB after ketamine during GA
- P = 0.81
Observational data: associations, not effects.
Further findings
Frontal SEF-95 after ketamine · 10-minute period after ketamine administration
- Significant increase in frontal SEF-95
- P < 0.001
Original publication
A Pilot Investigation Evaluating Relative Changes in Fronto-Occipital Alpha and Beta Spectral Power as Measurement of Anesthesia Hypnotic Depth. Anesth Analg. Published 24 March 2023. doi:10.
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