Permutation Entropy Does Not Track the Electroencephalogram-Related Manifestations of Paradoxical Excitation During Propofol-Induced Loss of Responsiveness: Results From a Prospective Observational Cohort Study
Authors' conclusion
PeEn and beta ratio seem suitable parameters to monitor the state transition during anesthesia induction.
Study context
- Population
- Patients undergoing GA with propofol-induced loss of responsiveness (LOR)
- Participants
- 60 patients
- Exposure
- EEG parameters before vs around propofol-induced LOR
- Outcome
- Change of EEG parameters around LOR
Main finding
As reported in the abstract
- Spectral edge frequency increased before LOR, from 19.78 [10.25-34.18] Hz to 25.39 [22.46-30.27] Hz
- P = .0122
- Spectral entropy increased before LOR, from 0.61 [0.54-0.75] to 0.77 [0.64-0.81]
- P < .0001
- Permutation entropy (PeEn) decreased from 0.78 [0.77-0.82] to 0.76 [0.73-0.81]
- P < .0001
- Beta ratio decreased from −0.74 [−1.14 to −0.09] to −2.58 [−2.83 to −1.77]
- P < .0001
Observational data: associations, not effects.
Original publication
Permutation Entropy Does Not Track the Electroencephalogram-Related Manifestations of Paradoxical Excitation During Propofol-Induced Loss of Responsiveness: Results From a Prospective Observational Cohort Study. Anesth Analg. Published 27 February 2024. doi:10. 1213/ ane. 0000000000006919
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