Anesthetic drugs & techniques

Permutation Entropy Does Not Track the Electroencephalogram-Related Manifestations of Paradoxical Excitation During Propofol-Induced Loss of Responsiveness: Results From a Prospective Observational Cohort Study

Anesth AnalgPublished Prospective observational cohort study

Authors' conclusion

PeEn and beta ratio seem suitable parameters to monitor the state transition during anesthesia induction.

Study context

Population
Patients undergoing GA with propofol-induced loss of responsiveness (LOR)
Participants
60 patients
Exposure
EEG parameters before vs around propofol-induced LOR
Outcome
Change of EEG parameters around LOR

Main finding

As reported in the abstract

Spectral edge frequency increased before LOR, from 19.78 [10.25-34.18] Hz to 25.39 [22.46-30.27] Hz
P = .0122
Spectral entropy increased before LOR, from 0.61 [0.54-0.75] to 0.77 [0.64-0.81]
P < .0001
Permutation entropy (PeEn) decreased from 0.78 [0.77-0.82] to 0.76 [0.73-0.81]
P < .0001
Beta ratio decreased from −0.74 [−1.14 to −0.09] to −2.58 [−2.83 to −1.77]
P < .0001

Observational data: associations, not effects.

Original publication

Permutation Entropy Does Not Track the Electroencephalogram-Related Manifestations of Paradoxical Excitation During Propofol-Induced Loss of Responsiveness: Results From a Prospective Observational Cohort Study. Anesth Analg. Published 27 February 2024. doi:10.1213/ane.0000000000006919

Composed by AI from the published abstract and checked against it. How Briefs are made →

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