Anaesthetic drugs & techniques
Effects of lidocaine bolus and infusion on neuromonitoring by bispectral index (BIS®), electroencephalogram periodic and aperiodic activity, and Surgical Pleth Index® during propofol–remifentanil anaesthesia: a single-centre prospective observational study
Authors' conclusion
When lidocaine is given during stable propofol-remifentanil anaesthesia, changes in spectral EEG parameters occur earlier than changes in BIS, SEF95 and SPI.
Study context
- Population
- Adult female patients undergoing breast surgery under stable propofol–remifentanil TCI, given i.v. lidocaine bolus (1.5 mg kg-1 over 10 min) then 30 min infusion (1.5 mg kg-1 h-1)
- Participants
- 20 patients
- Outcome
- Dose-dependent lidocaine effects on spectral EEG features and processed parameters BIS and SEF95
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Increase in delta-band and decrease in beta-band EEG activity 4 to 6 min after the bolus
- BIS and spectral edge frequency (SEF95) did not change significantly after the bolus
- Alpha peak bandwidth and centre frequency decreased significantly in the early period
- Aperiodic slope slightly but significantly increased after the bolus and during infusion
- During infusion, BIS and SEF95 significantly decreased after 12 to 15 min
- SPI significantly decreased in the later stages of the infusion phase
Observational data: associations, not effects.
Original publication
Effects of lidocaine bolus and infusion on neuromonitoring by bispectral index (BIS®), electroencephalogram periodic and aperiodic activity, and Surgical Pleth Index® during propofol–remifentanil anaesthesia: a single-centre prospective observational study. Br J Anaesth. Published 22 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →