Predictive pharmacodynamic performance of the Eleveld pharmacokinetic–pharmacodynamic model for propofol: comparison of predicted and measured bispectral index
Authors' conclusion
In spite of the acceptable MDPE and MDAPE, there are unacceptable degrees of both within-subject and between-subject variation during propofol target-controlled infusions.
Study context
- Population
- Adults undergoing lower limb surgery under total intravenous anaesthesia (TIVA) with remifentanil TCI and propofol manually controlled, target-guided infusions based on the Eleveld model
- Participants
- 40 adults
- Exposure
- Measured vs Eleveld model-predicted BIS during propofol TIVA
- Outcome
- Agreement between measured and predicted BIS values (median prediction errors, Bland-Altman analysis)
Methodological detailsmodel predictive performance evaluation, Bland-Altman analysis, Propofol infusions directed by PKPD Tools and StelSim simulation applications
- Model predictive performance evaluation
- Bland-Altman analysis
- Propofol infusions directed by PKPD Tools and StelSim simulation applications
Main finding
As reported in the abstract
Agreement of measured vs predicted BIS
MDPE (range −18.5 to 24.3)
−1.9
MDAPE (range 1.7 to 24.3)
10
Proportion of MDAPE >10 BIS units
47.8%
Bland-Altman mean bias, BIS units (limits of agreement −27.7 to 26.2)
−0.52
Observational data: associations, not effects.
Further findings
Bland-Altman analysis of Eleveld model supplementary data
- Similar results
Original publication
Predictive pharmacodynamic performance of the Eleveld pharmacokinetic–pharmacodynamic model for propofol: comparison of predicted and measured bispectral index. Br J Anaesth. Published 23 August 2024. doi:10.
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