Variability of predicted propofol concentrations and measured sevoflurane concentrations during general anaesthesia: a single-centre retrospective cohort study
Authors' conclusion
Improvements in prediction accuracy of pharmacokinetic models beyond that of those already in clinical use are unlikely to reduce variability in target anaesthetic concentrations across patients in clinical practice.
Study context
- Population
- Surgical procedures >1 h under GA with sevoflurane or propofol per institutional protocol
- Participants
- 2,280 surgical procedures
- Exposure
- Sevoflurane vs propofol target-controlled infusion (TCI), titrated to BIS 40-60
- Outcome
- Variability of required anaesthetic concentrations (normalized concentration range)
- Follow-up
- 30 min after skin incision
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Normalized concentration range · 30 min post-incision
Sevoflurane
0.89
99% CI 0.78–0.99
Propofol TCI
0.93
99% CI 0.87–1.02
Observational data: associations, not effects.
Further findings
| Outcome | Sevoflurane | Propofol TCI |
|---|---|---|
| Achieved BIS range (titration performance) · 30 min post-incision | 30 (99% CI 28–33) | 31 (99% CI 27–36) |
Achieved BIS range (titration performance) · 30 min post-incision
- Not significantly different
Original publication
Variability of predicted propofol concentrations and measured sevoflurane concentrations during general anaesthesia: a single-centre retrospective cohort study. Br J Anaesth. Published 3 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →