Pediatric anesthesia & critical care
BIS Guided Titration of Sevoflurane in Pediatric Patients Undergoing Elective Surgery: A Randomized Controlled Trial
Authors' conclusion
In pediatric participants, the BIS guided group reported a lower average end-tidal sevoflurane concentration compared to control, though no significant differences in recovery profile were noted.
Study context
- Population
- Children 4–18 years undergoing elective surgery with sevoflurane maintenancerandomized
- Participants
- 180 children
- Comparison
- BIS-guided sevoflurane titration vs control
- BIS guidedn = 84
- Controln = 86reference
- Primary endpoint
- Mean end-tidal sevoflurane concentration during maintenance phase of anaesthesia
Methodological detailsage-stratified (4-8, 9-12, 13-18 years), clinicians blinded to BIS in control
- Age-stratified (4-8, 9-12, 13-18 years)
- Clinicians blinded to BIS in control
Primary result
As reported in the abstract
Average end-tidal sevoflurane concentration, by age group
BIS guided vs ControlDifference (CI)
4-8 years
−0.3%(−0.4% to −0.1%)
9-12 years
−0.4%(−0.7% to −0.1%)
13-18 years
−0.3%(−0.5% to −0.1%)
Further findings
Recovery outcomes (time to discharge, PAED scale, modified Aldrete Score, Wong-Baker FACES)
- No differences in recovery outcomes between treatment groups
Original publication
BIS Guided Titration of Sevoflurane in Pediatric Patients Undergoing Elective Surgery: A Randomized Controlled Trial. Paediatr Anaesth. Published 4 January 2025. doi:10.
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