Pediatric anesthesia & critical care
Efficacy of Bispectral Index‐Guided Sevoflurane Administration in Pediatric Patients Undergoing General Anesthesia: An up‐To‐Date Systematic Review and Meta‐Analysis
Pooled result · Mean end-tidal sevoflurane concentration, maintenance phaseResult — go to the resultMD −0.46 95% CI −0.62 to −0.29Authors' conclusion
BIS-guided monitoring offers a strategy to reduce end-tidal sevoflurane concentrations, shortening time to airway removal and post-anesthesia care unit discharge in pediatric patients undergoing sevoflurane anesthesia.
Study context
- Population
- Pediatric patients undergoing GA with sevoflurane
- Participants
- 730 patients · 9 RCTs
- Comparison
- BIS-guided vs standard practice sevoflurane administration
- BIS-guidedn = 359
- Outcome
- Mean end-tidal sevoflurane concentration, maintenance phase
Pooled result
As reported in the abstract
MD
−0.46
95% CI −0.62 to −0.29
P < 0.00001
BIS-guided vs Standard practice
MD −0.46 (95% CI −0.62 to −0.29); P < 0.00001
Further pooled results
| Outcome | MD (95% CI) | P value | |
|---|---|---|---|
| Mean end-tidal sevoflurane concentration at end of surgery | −0.31 (−0.47 to −0.14) | P = 0.0003 | |
| −0.6−0.4−0.200.2Difference (linear scale) |
| Outcome | MD (min) (95% CI) | P value | |
|---|---|---|---|
| Time to airway removal | −1.69 (−2.84 to −0.55) | P = 0.004 | |
| Time to PACU discharge | −11.82 (−17.80 to −5.84) | P = 0.0001 | |
| −20−10010Difference, min (linear scale) |
Pediatric Anesthesia Emergence Delirium score
- No significant difference between groups
- MD −0.35; 95% CI: −1.90 to 1.19; p = 0.65
Original publication
Efficacy of Bispectral Index‐Guided Sevoflurane Administration in Pediatric Patients Undergoing General Anesthesia: An up‐To‐Date Systematic Review and Meta‐Analysis. Paediatr Anaesth. Published 22 November 2025. doi:10.
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