Pediatric anesthesia & critical care
Bispectral index-guided anesthesia in children: A systematic review and meta-analysis
Authors' conclusion
In children, BIS monitoring during general anesthesia limited the exposure to volatile anesthetics and is associated with better recovery outcomes.
Study context
- Population
- Children undergoing surgery under GA
- Participants
- 1,028 children · 10 randomized controlled trials (RCTs)
- Comparison
- BIS-guided GA vs GA guided only by clinical parameters
- BISn = 536
Further pooled results
| Outcome | MD (min) (95% CI) | P value | |
|---|---|---|---|
| Time to airway device removal | −1.32 (−2.26 to −0.37) | P < 0.01 | |
| Recovery time | −2.67 (−3.70 to −1.65) | P < 0.01 | |
| PACU stay duration | −5.51 (−10.64 to −0.38) | P = 0.04 | |
| −15−10−505Difference, min (linear scale) |
| Outcome | MD (%) (95% CI) | P value | |
|---|---|---|---|
| End-tidal sevoflurane concentration | −0.49 (−0.67 to −0.32) | P < 0.01 | |
| Time with an adequate BIS | 22.49 (17.80–27.18) | P < 0.01 | |
| −2002040Difference, % (linear scale) |
Anesthetic consumption, mean BIS during anesthesia, Pediatric Anesthesia Emergence Delirium (PAED) score at 10 and 30 min
- No differences between groups
Original publication
Bispectral index-guided anesthesia in children: A systematic review and meta-analysis. Anaesth Crit Care Pain Med. Published 29 September 2025. doi:10.
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