Neuromuscular end-point predictive capability of published rocuronium pharmacokinetic/pharmacodynamic models: An observational trial
Authors' conclusion
Simulated TOF ratios based on published PK/PD models do not accurately predict real intraoperative TOF ratio dynamics.
Study context
- Population
- Patients undergoing GA for elective surgery with rocuronium and continuous EMG neuromuscular monitoring, tertiary Belgian hospital, August 2020–September 2021
- Participants
- 74 patients
- Exposure
- Published rocuronium Pharmacokinetic (PK)/Pharmacodynamic (PD) model-predicted vs EMG-measured Train-of-four (TOF) ratios
- Outcome
- Performance of published rocuronium PK/PD models in predicting intraoperative TOF ratios vs electromyographic TOF measurements
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Prediction of intraoperative TOF ratios
| Group | Value | Wobble |
|---|---|---|
| Kleijn | median absolute performance error 16% (95% CI 0.01–57) | 11% (95%CI 0.01; 34) |
Kleijn
Valuemedian absolute performance error 16% (95% CI 0.01–57)
Wobble11% (95%CI 0.01; 34)
- Wierda, Szenohradszky, Cooper, Alvarez-Gomez and McCoy: median absolute performance errors
- between 38% and 41%
- Wierda, Szenohradszky, Cooper, Alvarez-Gomez and McCoy: Wobble
- between 14 and 15%
Observational data: associations, not effects.
Original publication
Neuromuscular end-point predictive capability of published rocuronium pharmacokinetic/pharmacodynamic models: An observational trial. J Clin Anesth. Published 3 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →