Intubating conditions based on the time from rocuronium administration versus the train-of-four count: A randomized, prospective, clinical trial
Authors' conclusion
Intubating conditions were better when the timing of intubation was guided by quantitative neuromuscular monitoring to ensure a TOF count ≤1 versus waiting a fixed time interval of 2 min following administration of rocuronium.
Study context
- Population
- Adults undergoing GA requiring neuromuscular block (propofol 1–1.5 mg/kg, rocuronium 0.6 mg/kg, video laryngoscopy, quantitative electromyographic monitoring)
- Participants
- 84 vs 83
- Comparison
- Intubation guided by train-of-four (TOF) count ≤1 vs fixed 2 min after rocuronium
- Countn = 84
- Timen = 83reference
- Primary endpoint
- Ideal intubating conditions (relaxed jaw, abducted vocal cords, and no response to tracheal intubation)
Methodological detailsprospective
- Prospective
Primary result
As reported in the abstract
Ideal intubating conditions
P = 0.036
Further findings
Mean
| Outcome | Count | Time | P value |
|---|---|---|---|
| Composite intubating score (lower = better) | 3.5 | 3.9 | P = 0.016 |
Correlation of T1/Tc at intubation with composite intubating score
- Spearman's ρ
- 0.34
- P < 0.001
Original publication
Intubating conditions based on the time from rocuronium administration versus the train-of-four count: A randomized, prospective, clinical trial. J Clin Anesth. Published 10 November 2025. doi:10.
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