Anaesthetic drugs & techniques
Characterization of the Bispectral Index in Healthy Volunteers Receiving Inhalation Anesthetics in Combination With Opioids in a Randomized Trial
Authors' conclusion
These results describe the relationship between BIS levels and responsiveness for commonly used volatile anesthetics, with and without opioids, across a range of anesthetic concentrations. The results of this study should be interpreted in light of the study design which included young, healthy adult volunteers with no sustained, noxious stimulation. These findings may not be generalizable to other populations or clinical situations.
Study context
- Population
- Healthy volunteers receiving inhaled anesthetics with or without intravenous opioidsn = 211 enrolled, 143 randomized to a treatment group and completed the procedure with adequate data
- Comparison
- Five anesthetic regimens: sevoflurane, sevoflurane with remifentanil, sevoflurane with fentanyl, desflurane, or isoflurane
- Primary endpoint
- BIS50 for each anesthetic regimen (BIS index at which 50% of participants were unresponsive, MOAA/S ≤2)
Primary result
As reported in the abstract
BIS50 across treatment groups, lowest
67.5 (95% confidence interval [CI], 63.6-71.4)
BIS50 across treatment groups, highest
76.2
73.5–78.8
Secondary outcomes
BIS95 (BIS index at which 95% of participants were unresponsive)
- BIS95 across treatment groups, lowest
- 49.1 (42.9-55.4)
- BIS95 across treatment groups, highest
- 63.3 (59.5-67.2)
BIS index as a predictor of responsiveness (AUC)
- AUCs across all treatment groups
- ≥0.95
- BIS indices were highly correlated with MOAA/S scores
Baseline characteristics
- Mean age
- 26.5 ± 6.7 years
- Male
- 52%
Safety
- No reported device-related adverse events
Original publication
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