Postanesthesia Care Unit Recovery Time According to Volatile Anesthetic Used in Clinical Practice
Main findingResult — go to the resultRatio of geometric means 0.96 98.3% CI 0.95–0.98Authors' conclusion
In clinical practice, only small, clinically unimportant differences in PACU recovery time were observed between the volatile anesthetics.
Study context
- Population
- Adults (≥18 years) undergoing surgery under GA with a volatile agent and admitted to the PACU, May 5, 2018 to December 31, 2020
- Participants
- 47,847 adults
- Exposure
- Isoflurane vs desflurane vs sevoflurane
- Isofluranen = 11,817reference
- Desfluranen = 11,286
- Sevofluranen = 24,744
- Outcome
- PACU recovery time (PACU admission to fulfillment of discharge criteria)
Methodological detailsobservational, inverse probability of treatment weighting, Bonferroni-adjusted pairwise comparisons
- Observational
- Inverse probability of treatment weighting
- Bonferroni-adjusted pairwise comparisons
Main finding
As reported in the abstract
Ratio of geometric means
0.96
98.3% CI 0.95–0.98
P < 0.001
By group
Sevoflurane vs Isoflurane
ratio of geometric means 0.96 (98.3% CI 0.95–0.98); P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Isoflurane | Desflurane | Sevoflurane | OR (98.3% CI) | P value | |
|---|---|---|---|---|---|---|
| Oversedation (Richmond Agitation-Sedation Scale score ≤−3)Desflurane vs Sevoflurane · IPTW-adjusted | 16.7% | 8.8% | 12.2% | 0.70 (0.62–0.79) | P < 0.001 | |
| Oversedation (Richmond Agitation-Sedation Scale score ≤−3)Desflurane vs Isoflurane · IPTW-adjusted | 0.48 (0.42–0.55) | P < 0.001 | ||||
| Oversedation (Richmond Agitation-Sedation Scale score ≤−3)Sevoflurane vs Isoflurane · IPTW-adjusted | 0.69 (0.63–0.76) | P < 0.001 | ||||
| 0.512Odds ratio (log scale) |
Oversedation (Richmond Agitation-Sedation Scale score ≤−3)
- Oversedated patients had longer PACU recovery time, but differences in oversedation rate across agents did not result in meaningful differences in time to PACU recovery
Original publication
Postanesthesia Care Unit Recovery Time According to Volatile Anesthetic Used in Clinical Practice. Anesth Analg. Published 15 September 2023. doi:10.
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