Ketamine Compared With Morphine for Out-of-Hospital Analgesia for Patients With Traumatic Pain: A Randomized Clinical Trial
Primary result · Mean pain score changeResult — go to the resultDifference in mean pain score change 0.1 points 95% CI −0.7 to 0.9Authors' conclusion
In the KETAMORPH study of patients with out-of-hospital traumatic pain, the use of intravenous ketamine compared with morphine showed noninferiority for pain reduction.
Study context
- Population
- Adults with out-of-hospital trauma and verbal pain score ≥5, 11 French out-of-hospital emergency medical units, 2017–2022ITT population
- Participants
- 251 adults
- Comparison
- IV ketamine vs IV morphine for out-of-hospital analgesia
- Ketaminen = 128
- Morphinen = 123reference
- Primary endpoint
- Between-group difference in mean change in verbal rating scale pain scores from before study drug to 30 minutes later (noninferiority margin 1.3)
- Follow-up
- 30 minutes
Methodological detailsmulticentre, single-blind, noninferiority
- Multicentre
- Single-blind
- Noninferiority
Primary result
Mean pain score change
Difference in mean pain score change
0.1 points
95% CI −0.7 to 0.9
Change by group
Ketamine
−3.7
mean · 95% CI −4.2–-3.2
Morphine
−3.8
mean · 95% CI −4.2–-3.4
As reported in the abstract
Further findings
Vital signs
- No clinically meaningful differences between the 2 groups
Safety
| Outcome | Ketamine | Morphine |
|---|---|---|
| Adverse effects | 40.8% (95% CI 32.0%–49.6%) | 16.8% (95% CI 10.4%–25.0%) |
| Denominator | 120 | 113 |
| Emergence phenomenon | 24 of 120 (20.0%) | — not stated in the abstract |
| Nausea | — not stated in the abstract | 12 of 113 (10.6%) |
— not stated in the abstract
Adverse effects
- No adverse events required intervention
Original publication
Ketamine Compared With Morphine for Out-of-Hospital Analgesia for Patients With Traumatic Pain: A Randomized Clinical Trial. JAMA Netw Open. Published 2 January 2024. doi:10.
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