Ketamine for postoperative pain treatment in spinal surgery: Systematic review with meta‐analysis and trial sequential analysis
Pooled result · Cumulative 24-h opioid consumption (adults)Result — go to the resultMean difference −17.57 mg 95% CI −24.22 to −10.92Authors' conclusion
In adults undergoing spinal surgery, ketamine may reduce cumulative 24-h opioid consumption. Ketamine may increase the occurrence of serious adverse events, but the evidence was very uncertain.
Study context
- Population
- Patients undergoing spinal surgery
- Participants
- 2,110 patients · 28 RCTs
- Comparison
- Ketamine vs placebo or no intervention
- Outcome
- Cumulative opioid consumption at 24 h postoperatively and serious adverse events
- Follow-up
- 24 h
Methodological detailstrial sequential analysis, Grading of Recommendations Assessment, Development and Evaluation (GRADE), 23 trials adults, 5 trials paediatric, 3 trials at low risk of bias
- Trial sequential analysis
- GRADE
- 23 trials adults, 5 trials paediatric
- 3 trials at low risk of bias
Pooled result
Cumulative 24-h opioid consumption (adults)
Mean difference
−17.57 mg
95% CI −24.22 to −10.92
P < 0.01
Ketamine vs Placebo or no intervention
mean difference −17.57 mg (95% CI −24.22 to −10.92); P < 0.01
As reported in the abstract
Safety
| Outcome | RR (96.7% CI) | P value | |
|---|---|---|---|
| Serious adverse events (adults)Very low certainty of evidence · co-primary outcome | 2.16 (0.35–13.17) | P = 0.36 | |
| 0.050.21520Relative risk (log scale) |
Original publication
Ketamine for postoperative pain treatment in spinal surgery: Systematic review with meta‐analysis and trial sequential analysis. Acta Anaesthesiol Scand. Published 19 July 2023. doi:10.
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