Lactate as a Predictor of Citrate Accumulation in Patients Undergoing Continuous Renal Replacement Therapy? A Systematic Review
Pooled result · Baseline lactateResult — go to the resultMD 0.87 95% CI 0.04–1.70Authors' conclusion
The evidence is very uncertain, but elevated lactate may be associated with an increased risk of CA in critically ill patients undergoing RCA-CRRT.
Study context
- Population
- Adult critically ill patients undergoing regional citrate anticoagulation continuous renal replacement therapy (CRRT) (RCA-CRRT)
- Participants
- 1,573 patients · 7 observational studies
- Comparison
- Lactate levels in patients with vs without citrate accumulation
- Outcome
- Lactate levels in patients with vs without CA
Methodological detailsFive studies good quality, two poor
- Five studies good quality, two poor
Pooled result
Baseline lactate
MD
0.87
95% CI 0.04–1.70
P = 0.04
CA vs non-CA
MD 0.87 (95% CI 0.04–1.70); P = 0.04
As reported in the abstract
Further pooled results
| Outcome | MD (95% CI) | P value | |
|---|---|---|---|
| Peak lactateThree studies, 271 patients | 6.05 (0.06–12.03) | P = 0.05 | |
| −5051015Difference (linear scale) |
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| MortalityFive studies, 1427 patients | 5.24 (1.05–26.25) | P = 0.04 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Lactate as a Predictor of Citrate Accumulation in Patients Undergoing Continuous Renal Replacement Therapy? A Systematic Review. Acta Anaesthesiol Scand. Published 19 May 2025. doi:10.
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