Lactated Ringer’s or Normal Saline for Initial Fluid Resuscitation in Sepsis-Induced Hypotension
Primary result · Death before discharge homeResult — go to the resultAdjusted hazard ratio 0.71 95% CI 0.51–0.99Authors' conclusion
Initial fluid resuscitation with lactated Ringer's solution, compared with 0.9% saline, might be associated with improved survival in patients with sepsis-induced hypotension.
Study context
- Population
- Adults with suspected or confirmed infection and sepsis-induced hypotension, ICUs and EDs in 60 US centers, 2018–2022
- Participants
- 1,563 CLOVERS participants
- Comparison
- Lactated Ringer's vs 0.9% saline for initial fluid resuscitation
- Lactated Ringer'sn = 622
- 0.9% salinen = 690reference
Methodological detailsmulticentre
- Multicentre
Primary result
Death before discharge home · day 90
Adjusted hazard ratio
0.71
95% CI 0.51–0.99
P = 0.043
Events by treatment group
Lactated Ringer's vs 0.9% saline
aHR 0.71 (95% CI 0.51–0.99); P = 0.043
As reported in the abstract
Further findings
| Outcome | Lactated Ringer's | 0.9% saline | Adjusted mean difference (d) (95% CI) | P value | |
|---|---|---|---|---|---|
| Hospital-free days · 28 days | 16.6 ± 10.8 | 15.4 ± 11.4 | 1.6 (0.4–2.8) | P = 0.009 | |
| −2024Difference, d (linear scale) |
Serum chloride and bicarbonate
- 0.9% saline associated with higher serum chloride and decreased serum bicarbonate
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Lactated Ringer’s or Normal Saline for Initial Fluid Resuscitation in Sepsis-Induced Hypotension. Crit Care Med. Published 19 February 2025. doi:10.
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