Cardiac arrest & resuscitation
Left-Ventricular Unloading With Impella During Refractory Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation: A Systematic Review and Meta-Analysis*
Pooled result · In-hospital mortalityResult — go to the resultOdds ratio 0.53 95% CI 0.30–0.91Authors' conclusion
ECMELLA support was predominantly used in patients with acute myocardial infarction and VA-ECMO for pulmonary embolism. ECMELLA support during ECPR might be associated with improved survival and neurologic outcome despite higher complication rates.
Study context
- Population
- Adults with refractory cardiac arrest receiving extracorporeal cardiopulmonary resuscitation (ECPR)13 study records
- Participants
- 1,014 adults · 32 hospitals
- Comparison
- ECMELLA vs venoarterial extracorporeal membrane oxygenation (VA-ECMO) alone during ECPR
- ECMELLAn = 252
- VA-ECMOn = 762reference
- Outcome
- In-hospital mortality
Methodological detailsrandom-effects model, Mantel-Haenszel, sensitivity analyses
- Random-effects model
- Mantel-Haenszel
- Sensitivity analyses
Pooled result
As reported in the abstract
Odds ratio
0.53
95% CI 0.30–0.91
ECMELLA vs VA-ECMO
OR 0.53 (95% CI 0.30–0.91)
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| Good neurologic outcome | 2.22 (1.17–4.22) | |
| 0.20.5125Odds ratio (log scale) |
Safety
- Numerically increased but not significantly higher complication rates with ECMELLA
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Left-Ventricular Unloading With Impella During Refractory Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation: A Systematic Review and Meta-Analysis*. Crit Care Med. Published 5 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →