Neuroanesthesia & neurocritical care
Liberal vs. restrictive transfusion strategy for acute brain injury: A meta-analysis with trial sequential analysis of randomized clinical trials
An erratum to this article was published (Anaesth Crit Care Pain Med, Sep 2026 ↗)
Pooled resultResult — go to the resultRelative risk 0.97 95% CI 0.83–1.14Authors' conclusion
In patients with acute brain injury, a restrictive transfusion strategy was not associated with worse neurological outcomes or higher mortality compared to a liberal strategy.
Study context
- Population
- Adults with acute brain injury
- Participants
- 2,599 adults · 6 randomized controlled trials (RCTs)
- Comparison
- Liberal vs restrictive RBC transfusion strategy
- Outcome
- Unfavorable neurological outcome
Methodological detailstrial sequential analysis
- Trial sequential analysis
Pooled result
As reported in the abstract
Relative risk
0.97
95% CI 0.83–1.14
P = 0.70
Liberal vs Restrictive
RR 0.97 (95% CI 0.83–1.14); P = 0.70
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Transfusion reactionNon-significantly more frequent with liberal transfusion | 1.13 (0.35–3.58) | P = 0.84 | |
| 0.20.5125Relative risk (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Liberal vs. restrictive transfusion strategy for acute brain injury: A meta-analysis with trial sequential analysis of randomized clinical trials. Anaesth Crit Care Pain Med. Published 13 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →