Perioperative medicine & outcomes
Lifestyle Optimization Leads to Superior Liver Regeneration in Live Liver Donors and Decreases Early Allograft Dysfunction in Recipients: A Randomized Control Trial
Authors' conclusion
Lifestyle optimization of LLD is simple to comply with, improves liver regeneration in LLDs, and decreases EGD in recipients, thus can enhance donor safety and outcomes in live donor liver transplantation.
Study context
- Population
- Fit live liver donors with no or minimal steatosis
- Participants
- 62 consecutive live liver donors (LLDs)
- Comparison
- Intervention vs Control
- Interventionn = 28
- Controln = 34reference
- Primary endpoint
- Day of normalization of serum bilirubin and PT-INR; percentage liver growth
- Follow-up
- POD 7 and 14
Primary result
As reported in the abstract
- Intervention vs Control: P = 0.005
- Intervention vs Control: P = 0.061
- Intervention vs Control: P = 0.03
Secondary outcomes
| Outcome | P value |
|---|---|
| Donor calorie intake, abdominal girth, BMI, weightIntervention vs Control · calorie intake decreased | P < 0.005 |
| Donor calorie intake, abdominal girth, BMI, weightIntervention vs Control · abdominal girth decreased | P < 0.005 |
| Donor calorie intake, abdominal girth, BMI, weightIntervention vs Control · BMI decreased | P = 0.05 |
| Donor calorie intake, abdominal girth, BMI, weightIntervention vs Control · weight decreased | P < 0.0005 |
| Blood loss, peak AST, ALT, steatosisIntervention vs Control · mean blood loss less | P = 0.038 |
| Blood loss, peak AST, ALT, steatosisIntervention vs Control · postoperative peak AST less | P = 0.003 |
| Blood loss, peak AST, ALT, steatosisIntervention vs Control · ALT less | P = 0.025 |
| Blood loss, peak AST, ALT, steatosisIntervention vs Control · steatosis less | P < 0.005 |
| Early graft dysfunction in recipientsEGD significantly higher in control recipients | P = 0.043 |
Liver-regeneration markers
- TNF-α, IL-6 and IL-10 significantly higher, TGF-β lower in intervention donors
Original publication
Lifestyle Optimization Leads to Superior Liver Regeneration in Live Liver Donors and Decreases Early Allograft Dysfunction in Recipients: A Randomized Control Trial. Ann Surg. Published 13 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →