Perioperative medicine & outcomes
Impact of a multimodal prehabilitation program on postoperative cognitive dysfunction: a single-center randomized controlled trial
Primary result · POCDResult — go to the resultOdds ratio 1.37 95% CI 0.54–3.50Authors' conclusion
In this randomized controlled trial, a 4-6-week multimodal prehabilitation program did not reduce postoperative cognitive dysfunction 3 months after cardiac surgery.
Study context
- Population
- Patients aged ≥50 years undergoing elective CABG and/or valve surgery116 completed 3-month follow-up
- Participants
- 134 patients
- Comparison
- 4-6 weeks multimodal prehabilitation vs standard preoperative care
- Prehabilitationn = 53
- Controln = 63reference
- Primary endpoint
- POCD (≥1.5 SD below normative values in at least 2 cognitive tests, excluding the Mini-Mental State Examination)
- Follow-up
- 3 months
Primary result
POCD
Odds ratio
1.37
95% CI 0.54–3.50
P = 0.52
Events by treatment group
Prehabilitation vs Control
OR 1.37 (95% CI 0.54–3.50); P = 0.52
As reported in the abstract
Further findings
Factors associated with postoperative cognitive dysfunction (POCD) (multivariable analysis): preoperative cognitive impairment
| OR (95% CI) | P value | ||
|---|---|---|---|
| Preoperative cognitive impairmentIndependently associated | 13.28 (4.06–43.41) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Factors associated with POCD (multivariable analysis): prehabilitationNot independently associated | 1.09 (0.35–3.45) | P = 0.877 | |
| 0.20.5125Odds ratio (log scale) |
Physical activity levels at 3 months and POCD
| OR (95% CI) | P value | ||
|---|---|---|---|
| Higher physical activity levelsAssociated with lower odds of POCD | 0.97 (0.95–1.00) | P = 0.047 | |
| 0.512Odds ratio (log scale) |
Original publication
Impact of a multimodal prehabilitation program on postoperative cognitive dysfunction: a single-center randomized controlled trial. J Clin Anesth. Published 14 August 2026. doi:10.
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