Neuroanesthesia & neurocritical care
Limitation of life sustaining measures in neurocritical care: sex, timing, and advance directive
Authors' conclusion
In patients receiving LLST, the presence of an AD was associated with an increase of early LLST, but not with an increased in-hospital mortality.
Study context
- Population
- All neurocritical care unit patients, 01.2018 to 08.2021
- Participants
- 2,975 patients
- Exposure
- Women vs men receiving limitation of life sustaining treatments (LLST); with vs without advance directives (AD)
- Outcome
- Associations of social/cultural factors with patients' sex, LLST timing and presence of AD
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
LLST
P = 0.30
Observational data: associations, not effects.
Further findings
Withdrawal instead of withholding of life sustaining treatments (patients receiving LLST) · despite comparable disease severity
P = 0.028
Without a partner (patients receiving LLST)
P = 0.001
Age (patients receiving LLST)
P = 0.005
- In-hospital mortality by AD: With AD 57.1%
- In-hospital mortality by AD: Without AD 75.2%
In-hospital mortality by AD
- AD associated with female sex and early LLST, but not with increased in-hospital mortality
Original publication
Limitation of life sustaining measures in neurocritical care: sex, timing, and advance directive. J Intensive Care. Published 16 January 2024. doi:10.
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