Sepsis & infection

Limited English Proficiency and Sepsis Mortality by Race and Ethnicity

JAMA Netw OpenPublished Retrospective cohort study

Main findingResult — go to the resultOdds ratio 1.12 95% CI 0.88–1.42

Authors' conclusion

In a large diverse academic medical center, LEP had no significant association overall with sepsis mortality. In a subgroup analysis, LEP was associated with increased mortality among individuals identifying as non-Hispanic White.

Study context

Population
Hospitalized adults with sepsis (CDC criteria, antibiotics within 24 hours, admitted through the ED), large New England tertiary care center, 2016–2019
Participants
2,709 adults
Exposure
Limited English proficiency vs English proficiency
  • Limited English proficiency (LEP)n = 327
  • English proficiency (EP)n = 2,382reference
Outcome
Inpatient mortality
Methodological detailssingle-centre, propensity score adjustment
  • Single-centre
  • Propensity score adjustment

Main finding

As reported in the abstract

Odds ratio

1.12

95% CI 0.88–1.42

Events by group

LEP vs EP
OR 1.12 (95% CI 0.88–1.42)

Observational data: associations, not effects.

Further findings

OutcomeEstimate
Inpatient mortality, non-Hispanic White (subgroup)LEP vs EPOR 1.76 (95% CI 1.41–2.21)
Inpatient mortality, non-Hispanic White (subgroup)LEP vs EP · adjusted analysisaOR 1.56 (95% CI 1.02–2.39)
Inpatient mortality, racial and ethnic minority (subgroup)LEP vs EPOR 0.99 (95% CI 0.63–1.58)
Inpatient mortality, racial and ethnic minority (subgroup)LEP vs EP · adjusted analysisaOR 0.91 (95% CI 0.56–1.48)

Original publication

Limited English Proficiency and Sepsis Mortality by Race and Ethnicity. JAMA Netw Open. Published 2 January 2024. doi:10.1001/jamanetworkopen.2023.50373

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