ICU sedation, delirium & recovery
Long-term frailty trajectory in older intensive care unit (ICU) survivors requiring mechanical ventilation: a prospective cohort study in Norway
Authors' conclusion
In elderly ICU-patients long-term frailty is deranged, and baseline CFS is closely associated with mortality. However, a small group of patients had a transitory decline in frailty at three months follow-up and then improved.
Study context
- Population
- Patients aged ≥65 years requiring invasive mechanical ventilation for ≥24 h in five Norwegian hospitals
- Participants
- 346 patients
- Outcome
- Long-term mortality and frailty trajectories (CFS: robust 1-3, prefrail 4, frail ≥5)
- Follow-up
- 3 and 12 months
Methodological detailsobservational, multicentre (five Norwegian hospitals)
- Observational
- Multicentre (five Norwegian hospitals)
Main finding
As reported in the abstract
Mortality and frailty trajectory
- Total mortality
- 52 %
- Frailty prevalence in survivors, baseline
- 23 % (79/346)
- Frailty prevalence in survivors, 3 months
- 47 % (81/174)
- Clinical Frailty Scale (CFS) unchanged between 3 and 12 months
- 71 % (108/153)
- CFS improved between 3 and 12 months
- 19 % (29/153)
- CFS deteriorated between 3 and 12 months
- 10 % (15/153)
Observational data: associations, not effects.
Further findings
Predictors of 12-month mortality
| RR | P value | |
|---|---|---|
| Baseline CFSStrongest association | 1.46 | P < 0.001 |
| Age | 1.22 | P < 0.001 |
| SOFA score day 1 after intubation | 1.14 | P < 0.01 |
- Comorbidity not a significant predictor
Living situation · 12 months
%
- Returned home
- 86 (132/153)
- Required home care (vs 10 % pre-admission)
- 32 (49/153)
Original publication
Long-term frailty trajectory in older ICU survivors requiring mechanical ventilation: a prospective cohort study in Norway. Ann Intensive Care. Published 16 July 2026. doi:10.
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