Long-term Outcomes Following a Comprehensive Quality Assurance and Process Improvement Endeavor to Minimize Opioid Use After Kidney Transplant
Authors' conclusion
The study's findings show a significant reduction in opioid use in kidney graft recipients associated with the implementation of a multimodal opioid-sparing pain protocol.
Study context
- Population
- Adult kidney graft recipients, August 1, 2017, through June 30, 2020
- Participants
- 743 recipients
- Exposure
- Postprotocol vs Preprotocol
- Postprotocoln = 498
- Preprotocoln = 245reference
- Outcome
- Opioid use before and after protocol implementation
- Follow-up
- Up to 1 year after transplant
Methodological detailssingle-centre, before-and-after, retrospective chart review, multivariable linear and logistic regression
- Single-centre
- Before-and-after
- Retrospective chart review
- Multivariable linear and logistic regression
Main finding
As reported in the abstract
Total morphine milligram equivalents (MME) in 1-year follow-up · up to 1 year
Observational data: associations, not effects.
Further findings
| Outcome | Postprotocol | Preprotocol | Estimate | P value | |
|---|---|---|---|---|---|
| 0 MME in 1-year follow-up | 62.9% | 2.9% | OR 57.52 (95% CI 26.55–124.65) | ||
| Filling >100 MME in 1-year follow-up99% lower odds | aOR 0.01 (95% CI 0.01–0.02) | P < 0.001 | |||
| Becoming long-term opioid user (opioid-naive subgroup) | OR 0.44 (95% CI 0.20–0.98) | P = 0.04 | |||
| 0.050.21520Ratio (log scale) |
Original publication
Long-term Outcomes Following a Comprehensive Quality Assurance and Process Improvement Endeavor to Minimize Opioid Use After Kidney Transplant. JAMA Surg. Published 1 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →