Respiratory failure & ventilation
Longitudinal proteomic analysis of pathophysiology in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome (ARDS)
Authors' conclusion
In BALF in the acute phase, humoral immunity, mainly B-cell receptor signaling, was activated, whereas the HSP90 cycle and protein folding mechanisms were inactivated.
Study context
- Population
- Adult patients with ARDS
- Participants
- 21 vs 24
- Exposure
- Acute vs subacute phase of ARDS
- ARDSn = 21
- Healthy donorsn = 24reference
- Outcome
- Proteomic profiles of plasma and BALF in the acute and subacute phases
Methodological detailssingle-centre, longitudinal proteomic analysis (mass spectrometry)
- Single-centre
- Longitudinal proteomic analysis (mass spectrometry)
Main finding
As reported in the abstract
Proteomic profiles (694 plasma, 2017 BALF proteins analysed)
- Coagulation and complement processes, activated in plasma and bronchoalveolar lavage fluid (BALF), more pronounced in acute than subacute phase
- Acute-phase BALF: humoral and immune response pathways activated; chaperone and protein folding processes suppressed
- IPA: B cell receptor signaling most activated; HSP90 chaperone cycle, protein folding and cellular stress response pathways suppressed
- Most activated upstream regulator IFN-γ; most suppressed NOTCH1
Observational data: associations, not effects.
Original publication
Longitudinal proteomic analysis of pathophysiology in plasma and bronchoalveolar lavage fluid of patients with ARDS. J Intensive Care. Published 15 May 2025. doi:10.
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